Blood Pressure Medicine Types

Author: Dr. Vrolijk   |   Updated: August 23, 2025   |   Disclaimer   |   Review Process   |   References

Author: Dr. Vrolijk   

Updated: August 23, 2025   

Disclaimer   |   Review Process   |   References

Starting blood pressure medicine can feel overwhelming. You might have questions about side effects, worry about taking pills every day, or wonder if there’s a better option for your situation.

This page covers why blood pressure medicine can keep you healthy, the main kinds, and what to do if you have side effects.

On This Page:

Older woman holding glass of water while taking daily blood pressure medication at home

Who Needs Medicine?

You need blood pressure lowering medication when your blood pressure might cause health problems like a stroke or heart attack. You can figure out how likely these health problems are based on:

  • Health conditions you have that put you at risk (like diabetes or kidney disease)
  • How high your blood pressure is

Blood pressure medicine can protect you by reducing the damage caused by high blood pressure.

Treatment Based on Blood Pressure

Chart showing blood pressure treatment ranges. High normal: 120-129 over 80 or less requires diet and lifestyle changes, with medication for some.

Diet & Lifestyle   

→ Learn more: Simple Lifestyle Changes for Lower Blood Pressure

Chart showing Stage 1 Hypertension blood pressure ranges: top number 130-139 or bottom number 80-89. Yellow slow sign indicates caution needed.
  • Diet & Lifestyle 
  • Medicine if you have (1 or more):
    • Heart disease
    • Kidney disease
    • Previous stroke
    • 65 or older
    • High risk of developing heart disease
Chart showing Stage 2 Hypertension blood pressure ranges: top number 140 or more or bottom number 90 or more. Red alert icon shows urgency.
  • Usually Needs Medicine: Important to protect your body
  • Diet & Lifestyle

Main Blood Pressure Medications

The Best Medicine(s) for You Depends on Your Body

Each medicine works differently. Some can help with other health problems. For example, ACE inhibitors and ARBs protect the heart and lower blood pressure. So, they can help someone who had a heart attack. 

Click on the type of medicine to learn more

Why Doctors Choose ACE Inhibitors

Good choice for most people. Especially helpful if you have kidney disease or heart problems. Protects your heart and kidneys while lowering blood pressure.

Common Side Effects & What You Can Do

Dry Cough
  • Tell your doctor—they might switch you to ARBs
  • The cough usually goes away with different medicine
Lightheaded when You Stand Up
  • Tell your doctor—they might suggest changing the dose

  • Stand up slowly

  • Make sure to drink enough water

  • Ask your doctor about taking the medication at night instead of in the morning

Kidney Changes on Blood Tests
  • Regular blood tests catch changes early
  • Changing medicine fixes most changes

🚨 Get Emergency Help if You Have

  • Swelling of the face, lips, or tongue
  • Trouble breathing
  • Really bad stomach pain, diarrhea, or throwing up

Why Doctors Choose Calcium Channel Blockers

Work well for many people, especially older adults. Good choice if you have certain heart rhythms (atrial fibrillation). Some types are safe during pregnancy.

Common Side Effects & What You Can Do

Ankle Swelling
  • Elevate feet when resting
  • Stay active by walking
  • Tell your doctor, they might suggest:
    • Changing your dose​
    • Switching to a different kind of calcium channel blocker
    • Adding an ACE inhibitor or ARB to stop the swelling
Headache or Flushing

Tell your doctor, they:

  • Might suggest changing the dose
  • Can let you know if it might get better with time
  • Can tell you if taking it at a different time of day might help
Trouble Pooping (Constipation)
  • Eat more fiber-rich foods (like fruits and vegetables)
  • Stay active by walking
  • Ask your doctor about diet changes that might help
  • Talk to your doctor – they might suggest changing the dose or trying a different medicine
Gum Problems (Gingival Hyperplasia)
  • Brush teeth at least twice daily
  • Floss at least once a day
  • See your dentist regularly
  • Tell your dentist about this medicine
  • Tell your doctor – they may suggest a different medication

Why Doctors Choose ARBs

Work like ACE inhibitors but won’t cause coughing. Often chosen if you can’t take ACE inhibitors. Protects your kidneys and heart while lowering your blood pressure.

Common Side Effects & What You Can Do

Lightheaded when You Stand Up
  • Tell your doctor—they might suggest changing the dose

  • Stand up slowly

  • Make sure to drink enough water

  • Ask your doctor about taking the medication at night instead of in the morning

Kidney Changes on Blood Tests
  • Regular blood tests catch changes early
  • Changing medicine fixes most changes

Why Doctors Choose Diuretics

Often work well with other blood pressure medicines. Usually used if you have problems with low calcium, kidney stones, or swelling.

Common Side Effects & What You Can Do

More Bathroom Trips
  • Take the medicine in the morning
  • Plan activities where you’ll have bathroom access
  • Eat less salt – Can help the medicine work better. This means your doctor may be able to lower your dose over time.
  • Talk to your doctor – They can suggest ways to help or another medicine
Changes on Blood Tests
  • Regular blood tests catch changes early
  • Your doctor might suggest supplements 
Changes in Blood Sugar
  • Regular blood tests help catch changes early
  • Your doctor can help adjust or change your medicine
Feeling Thirsty or Dehydrated
  • Sip water throughout the day
  • Ask your doctor how much water is right for you
  • Tell your doctor if you’re having trouble drinking enough water
Trouble Sleeping
  • Take medicine in the morning
  • Keep a regular sleep schedule
  • Talk to your doctor – They might suggest a different medication or timing

Lifestyle Only

healthed4everyone-jogging-group

Benefits

  • Lowers blood pressure naturally
  • Better health overall
    • More energy
    • Feel healthier and fitter

Challenges

  • Takes longer to see results
  • Some people can’t lower their blood pressure enough. This is based on:
    • Your genes​
    • Age
    • Other health conditions
    • How high your blood pressure is
  • You have to do it everyday

Risks

  • Longer time with high blood pressure
  • Continued risk of health problems
    • Brain: stroke​
    • Heart: heart attack
    • Kidneys: chronic kidney disease
  • Harder to reverse damage once it happens
  • May miss the window for prevention

Quick Answers

What is the best blood pressure medicine with the least side effects?

This is one of the most common questions. The truth is, there isn’t one “winner.” Which is in many ways good news because it means you have options.

All four medication types are the first choices because they work well for most people. The best one for you might also help with another health condition. So, each person has a different best medication or medications.

Does blood pressure medicine cause you to gain weight?

Most people will not gain weight from blood pressure medicine. Some people might notice water weight gain, but this is usually from heart problems, not the medicine itself.

Amlodipine is different. About 1 in 10 people taking amlodipine get ankle or foot swelling. This swelling is from extra water, not fat, and happens because the medicine opens up blood vessels.

This swelling usually goes away within a few days once it’s treated.

 

More about Swelling from Amlodipine

  • Usually starts after taking the medicine for several weeks or months
  • Is more likely with higher doses
  • Can be bothersome but is not dangerous
 

What You Can Do if This Happens

  • Elevate your feet when resting
  • Stay active – walking helps
  • Tell your doctor – they can often help by:
    • Lowering your dose
    • Adding another medicine
    • Switching to a different blood pressure medicine
How do doctor's decide on which medicine to prescribe?

It’s a good idea to still talk to your doctor. Together you can figure out if there’s a pattern. You should keep checking your blood pressure 1-2 times a day. Write down your readings and how you feel.

What will happen if I don't treat high blood pressure?

High blood pressure damages your body slowly over time. You can’t feel it happening.

What Can Get Damaged
  • Heart – Works too hard, can get bigger and weaker
  • Blood vessels – Get stiff and narrow
  • Brain – Blood vessels can burst or get blocked
  • Kidneys – Can get damaged and not work as well
  • Eyes – Can hurt your vision
How Long Does It Take to Happen?
  • Damage happens over months and years
  • Some damage can’t be fixed once it happens
  • The higher your blood pressure, the faster damage occurs
What should I expect when I start taking blood pressure medicine?

Most medications start working within a few hours. But don’t worry if you don’t feel anything different! High blood pressure usually doesn’t cause symptoms, so you won’t feel the medication working.

Some people feel a little lightheaded for the first few days as their body gets used to the lower blood pressure. This usually gets better. But tell your doctor if you feel very lightheaded or might fall.

It takes about 2-4 weeks to see the full effect on your blood pressure readings.

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